David Barua, MS

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PhD Candidate

Discipline of Pathology

School of Medicine

National University of Ireland, Galway (NUIG)

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David Barua is currently pursuing a PhD in Pathology, School of Medicine at the National University of Ireland, Galway (NUIG). His research is mainly focused on understanding the role of unfolded protein response in ER-positive breast cancer and endocrine resistance. He also worked on ESR1 point mutant breast cancer cells and finding alternative treatment strategies to overcome the endocrine resistance. He completed a BSc (Honours) and MS in Biochemistry and Molecular Biology from the University of Chittagong, Bangladesh. He did his masters thesis under the supervision of Prof. Dr. Abu Shadat M. Noman, where he worked to understand the status of sonic hedgehog in bladder cancer. After completing masters, he worked as a research assistant in the EuGEF laboratory, where he was involved in several projects on breast cancer. He awarded the Irish Research Council (IRC) postgraduate scholarship to pursue PhD in Ireland. He is the lead author and co-author of several scientific publications and presented his research in international conference, including AACR. He is a member of the American Association for Cancer Research (AACR), European Association for Cancer Research (EACR).   

     

 

Selected Publications:

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• D Barua, A Gupta, S Gupta. Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges. Cancer Letters (2020) https://doi.org/10.1016/j.canlet.2020.05.020.

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• D Barua, B Abbasi, A Gupta, S Gupta XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation. Heliyon (Cell Press Journal) (2020) https://doi.org/10.1016/j.heliyon.2020.e05217.

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• M M Hossain, A Sultana, D Barua, N Islam, A Gupta, S Gupta. Differential Expression, Function and Prognostic Value of miR-17-92 Cluster in ER-positive and Triple-negative Breast Cancer. Cancer Treatment and Research Communications (2020) https://doi.org/10.1016/j.ctarc.2020.100224. 

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• M M Hossain, D Barua, V Arabkari, N Islam, A Gupta, S Gupta. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget (2018) doi: 10.18632/oncotarget.24451.

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• AS Noman, M Uddin, AA Chowdhury, MJ Nayeem, Z Raihan, MI Rashid, AK Azad, ML Rahman, D Barua, A Sultana, et. al.; Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Scientific Reports (2017) doi: 10.1038/s41598-017-01268-4.

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• Islam SS, Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, et. al.; Overexpression of sonic hedgehog in the triple negative breast cancer: Clinicopathological Characteristics of high burden breast cancer patients from Bangladesh. Scientific Reports (2016) doi: 10.1038/srep18830.